500 mg 90 veg caps
Suggested Use: Take 1 capsule one time up to three times daily with food or as directed by your healthcare provider.
Note: Recommended by Sunil Pai, MD for use when beta glucuronidase levels are elevated on GI Effects testing.
Sanjevani Calcium D-Glucarate is a patented form of D-glucarate (also known as D-glucaric acid), a naturally occurring substance in the body that is involved in the metabolism and disposal of toxins and excess hormones, such as estrogen. In the diet, D-glucarate is found primarily in fruits and vegetables such as apples, grapefruit, oranges, bean sprouts, and broccoli. It is also produced in small amounts in the body.
Sanjevani Calcium D-Glucarate supports Phase II glucuronidation, a primary detoxification pathway that deactivates toxins and promotes their elimination.† D-glucarate plays a vital protective role for the immune system by inhibiting the beta-glucuronidase enzyme that can otherwise interfere with safe removal of steroid hormones such as estrogen.† Beta-glucuronidase enzymes are active throughout the body, especially in the liver, colon, lungs, skin, bladder, breast, and prostate.
Studies show that Calcium D-Glucarate supplementation supports healthy immune function, promotes estrogen metabolism, and enhances the body’s detoxification systems through inhibition of beta-glucuronidase, an enzyme that can interfere with normal hormone metabolism.
Upon ingestion, D-glucarate is slowly released from Calcium D-Glucarate and forms a compound that inhibits the enzyme beta-glucuronidase. This enzyme reduces the excretion of toxins and steroid hormones, including estrogen. Although beta-glucuronidase has some useful functions in the body, it can become overactive as a result of shifts in the gut microbiome, allowing toxins and hormones to be reabsorbed back into the body instead of being excreted.
The slow-release nature of Calcium D-Glucarate inhibits about 50% of the enzyme activity over a five-hour period, thus helping the body to safely remove undesirable amounts of estrogen and other compounds. Because beta-glucuronidase enzymes are present in the liver, kidney, spleen, intestines, reproductive organs, and many other tissues, the beneficial actions of Calcium D-Glucarate may occur throughout the body.
For general daily use, 1 500 mg capsule daily is sometimes recommended. Research on Calcium D-Glucarate demonstrating inhibition of beta-glucuronidease begins with amounts of 1,500 mg per day and goes up to 9 grams per day. Individuals with higher environmental exposures, or increased needs to metabolize estrogen or other hormones, can take 3 or more capsules per day.
FOOD AND DRUG ADMINISTRATION (FDA) DISCLOSURE
†*All these statements and information on the product descriptions and this website have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, or cure any disease. Always check with your physician before starting a new dietary supplement program.